Letrozole Mode of Action

Letrozole Mode of Action

Letrozole is a medication commonly used in the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by blocking the enzyme aromatase that converts androgens (hormones produced by the adrenal glands) into estrogen. This inhibition leads to a decrease in estrogen levels in the body, which can help slow or stop the growth of estrogen-sensitive tumors.

Mechanism of Action

Letrozole works by binding to the active site of the aromatase enzyme, preventing it from converting androgens into estrogen. By inhibiting this conversion, letrozole effectively reduces the overall levels of estrogen in the body. This is particularly beneficial in the treatment of hormone receptor-positive breast cancer, where estrogen fuels the growth of cancer cells.

Impact on Breast Cancer Treatment

By lowering estrogen levels, letrozole helps to deprive estrogen-sensitive breast cancer cells of the hormones they need to grow and multiply. This can lead to tumor shrinkage, slowing down disease https://letrozole-for-sale.com/medicament/letrozol-mylan-filmtabletten-2-5mg-100-stuck/ progression, and reducing the risk of recurrence. Letrozole is often prescribed as part of adjuvant therapy in postmenopausal women with early-stage breast cancer, as well as for metastatic breast cancer.

Overall, the mode of action of letrozole demonstrates its effectiveness in targeting hormone-sensitive breast cancer cells by reducing estrogen production. Its mechanism as an aromatase inhibitor makes it a valuable treatment option in the fight against breast cancer.

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